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apalutamide will lessen the level or result of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medicine which might be CYP3A4 substrates can result in lower exposure to these medicines.bosentan will decrease the extent or impact o